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Clinical Trial
. 1999 Mar;79(7-8):1179-81.
doi: 10.1038/sj.bjc.6690188.

A high incidence of vertebral fracture in women with breast cancer

J A Kanis  1 , E V McCloskey, T Powles, A H Paterson, S Ashley, T Spector
Affiliations
Free PMC article
Clinical Trial

A high incidence of vertebral fracture in women with breast cancer

J A Kanis et al. Br J Cancer. 1999 Mar.
Free PMC article

Abstract

Because treatment for breast cancer may adversely affect skeletal metabolism, we investigated vertebral fracture risk in women with non-metastatic breast cancer. The prevalence of vertebral fracture was similar in women at the time of first diagnosis to that in an age-matched sample of the general population. The incidence of vertebral fracture, however, was nearly five times greater than normal in women from the time of first diagnosis [odds ratio (OR), 4.7; 95% confidence interval (95% CI), 2.3-9.9], and 20-fold higher in women with soft-tissue metastases without evidence of skeletal metastases (OR, 22.7; 95% CI, 9.1-57.1). We conclude that vertebral fracture risk is markedly increased in women with breast cancer.

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