doi: 10.1111/j.1432-1033.1976.tb10956.x.
On the initiation of mammalian RNA polymerase at single-strand breaks in DNA
- PMID: 1009933
- DOI: 10.1111/j.1432-1033.1976.tb10956.x
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On the initiation of mammalian RNA polymerase at single-strand breaks in DNA
Eur J Biochem.
.
Free article
Abstract
Mammalian RNA polymerase B is able to initiate at single-strand breaks in the DNA template. A 3'-OH end at a nick is required for initiation whereas the 5'-end may be either -- OH or phosphate. The 3'-OH group does not function as a primer. An appreciable part of the newly synthesized RNA started at a nick remains associated with the DNA in hydrid form. Initiation of exogeneous RNA polymerase B on chromatin exhibits similar requirements.
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