The role of oxidized low-density lipoprotein in the activation of peroxisome proliferator-activated receptor gamma: implications for atherosclerosis

Abstract

A molecular mechanism has been discovered that helps explain the formation of foam cells, which are components of atherosclerotic plaque. It involves the stimulation by oxidized low-density lipoprotein of its own uptake into macrophages through activation of the peroxisome proliferator-activated receptor gamma.