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. 1999 Apr;43(4):947-9.
doi: 10.1128/AAC.43.4.947.

Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium

N A el Amin  1 , S Jalal, B Wretlind
Affiliations

Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium

N A el Amin et al. Antimicrob Agents Chemother. 1999 Apr.

Abstract

High-level quinolone resistance in Enterococcus faecium was associated with mutations in both gyrA and parC genes in 10 of 11 resistant strains. On low-level resistant strain without such mutations may instead possess an efflux mechanism or alterations in the other subunits of the gyrase or topoisomerase IV genes. These findings are similar to those for other gram-positive bacteria, such as Enterococcus faecalis.

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Figures

FIG. 1
FIG. 1
E. faecium (Efem) GyrA (A) and ParC (B) partial gene sequences, compared with those of E. faecalis (Efecl), S. pneumoniae (Spn), and E. coli. The numbered amino acids start from the first amino acid in the complete sequence of E. coli and in partial sequences of the others. Only amino acids that differ from those of E. faecium are shown. Asterisks mark the mutation points.
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