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. 1999 Apr;43(4):954-6.
doi: 10.1128/AAC.43.4.954.

Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis

C M Bebear  1 , J Renaudin, A Charron, H Renaudin, B de Barbeyrac, T Schaeverbeke, C Bebear
Affiliations

Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis

C M Bebear et al. Antimicrob Agents Chemother. 1999 Apr.

Abstract

Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates were probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance-determining regions of both DNA gyrase (GyrA) and topoisomerase IV (ParC or ParE). Furthermore, the novobiocin MIC for three isolates showed a significant increase. This is the first characterization of fluoroquinolone-resistant clinical mycoplasma isolates from humans.

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References

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