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. 1976 Sep-Oct;71(5):469-81.
doi: 10.1007/BF01909763.

The influence of calcium and beta-sympathomimetics on force-frequency relationship and resting potentiation in guinea pig papillary muscle

M Hanafy, J Kitzing, E Rumberger

The influence of calcium and beta-sympathomimetics on force-frequency relationship and resting potentiation in guinea pig papillary muscle

M Hanafy et al. Basic Res Cardiol. 1976 Sep-Oct.

Abstract

The influence of various calcium concentrations and of the beta-sympathomimeticum orciprenaline (Alupent) on the force-frequency relationship and on the resting potentiation of isolated isometrically contracting papillary muscles of the guinea pig heart was studied. Elevation of Ca concentration and/or addition of orciprenaline augment the amplitudes of contractions elicited by rhythmical stimulation, but they diminish the amplitudes of test contractions elicited after a test interval of 1-2 s. It is suggested that calcium and orciprenaline strengthen the calcium loss from the sarcoplasmic reticulum out of the cell during a prolonged interval.

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