A further pancreatic carcinogen in Syrian golden hamsters: N-nitroso-bis(2-acetoxypropyl)amine

Abstract

Weekly subcutaneous injection of N-nitroso-bis(2-acetoxypropyl)amine (BAP) for 20 weeks to Syrian golden hamsters induced pancreatic neoplasms in 50% of the animals, as early as 15 weeks from the start of treatment. The carcinogenic potency and organotropic spectrum of BAP were similar to those of N-nitroso-bis(2-hydroxypropyl)amine (BHP). Metabolism studies indicated that BAP was readily converted in vivo to BHP and that BHP was also the major urinary metabolite.