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. 1976 Dec;13(6):496-500.
doi: 10.1136/jmg.13.6.496.

Dicentric X isochromosomes in man

R T Howell, S H Roberts, R J Beard

Dicentric X isochromosomes in man

R T Howell et al. J Med Genet. 1976 Dec.

Abstract

Four cases of Turner's syndrome are presented in which an apparent X isochromosome i(Xq) has been found to possess two regions of centromeric heterochromatin. It is suggested that these chromosomes were isodicentric structures capable of functioning as monocentric elements as a result of the inactivation of one centromere. The prevalence of mosaicism is believed to be a consequence of the dicentric nature of these chromosomes, and it is considered possible that a high proportion of X isochromosmes are structurally dicentric. Banding patterns showed that the exchange site involved in the formation of the dicentric chromosome was different in at least three of the cases.

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