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. 1998 Aug;43(2):294-9.
doi: 10.1136/gut.43.2.294.

Salt and water absorption in the human colon: a modern appraisal

G I Sandle  1
Affiliations

Salt and water absorption in the human colon: a modern appraisal

G I Sandle. Gut. 1998 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Proposed cellular model of electrogenic Na+ absorption in human colon. This process is located predominantly in surface colonocytes.616 Apical Na+ entry is passive, channel mediated, and inhibited by amiloride. Basolateral Na+ extrusion is mediated by Na+,K+-ATPase (the electrogenic "Na+ pump").
Figure 2
Figure 2
Proposed cellular model of electroneutral NaCl absorption in human colon. This process is localised to surface colonocytes. Apical Na+ uptake is mediated by Na+-H+ exchange, most likely linked by intracellular pH to apical Cl -HCO3 exchange.8936 It is not known whether human colonic crypts cells exhibit an electroneutral Na+ absorptive process similar to that identified in rat distal colonic crypts.438
Figure 3
Figure 3
Initial proposed cellular model linking butyrate (But) absorption to electroneutral NaCl absorption (see text for details). Adapted from Rajendran and Binder.50
Figure 4
Figure 4
Current proposed cellular model of butyrate (But) stimulated electroneutral NaCl absorption (see text for details). Adapted from Rajendran and Binder.50
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