Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1998 Nov;51(11):872-4.
doi: 10.1136/jcp.51.11.872.

Histochemical investigation into the molecular mechanisms of malignant transformation in a benign glomus tumour

Affiliations
Case Reports

Histochemical investigation into the molecular mechanisms of malignant transformation in a benign glomus tumour

L Hegyi et al. J Clin Pathol. 1998 Nov.

Abstract

A glomangiosarcoma arose in a benign glomus tumour. The histological and immunohistochemical characteristics of the tumour were investigated. Apoptotic cells were identified by terminal deoxynucleotidyl transferase (TdT) mediated dUTP-biotin nick end labelling (TUNEL). The proportion of apoptotic cells was found to be low and TUNEL positive nuclei were present in the benign part of the tumour. Bcl-2 protein, an inhibitor of apoptosis, was strongly expressed in the glomangiosarcoma with only weak staining in the benign area. The proliferation index of the glomangiosarcoma was almost 10-fold higher than that of the benign glomus tumour. Numerous nuclei in the glomangiosarcoma were intensely stained for the tumour suppressor protein p53. The results of the this study may contribute to an understanding of the molecular basis of malignant transformation in benign glomus tumours.

PubMed Disclaimer

References

    1. Cancer. 1988 Apr 1;61(7):1467-71 - PubMed
    1. J Cell Sci. 1989 Apr;92 ( Pt 4):531-40 - PubMed
    1. Cancer. 1990 Jan 15;65(2):310-8 - PubMed
    1. J Pathol. 1996 Dec;180(4):423-9 - PubMed
    1. Br J Cancer. 1993 Oct;68(4):653-61 - PubMed

Publication types

LinkOut - more resources