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. 1998 Dec;39(4):271-8.
doi: 10.1269/jrr.39.271.

Effects of X-ray irradiation on genomic DNA methylation levels in mouse tissues

R Tawa  1 , Y Kimura, J Komura, Y Miyamura, A Kurishita, M S Sasaki, H Sakurai, T Ono
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Free article

Effects of X-ray irradiation on genomic DNA methylation levels in mouse tissues

R Tawa et al. J Radiat Res. 1998 Dec.
Free article

Abstract

Effects of ionizing radiation on the level of genomic DNA methylation in liver, brain and spleen of mouse as well as in two kinds of cultured cells were examined by high-performance liquid chromatography. Ten Gy of whole body X-radiation reduced the 5-methyldeoxycytidine contents by about 40% within 8 hours after irradiation in liver. Similar effects were observed at 4 or 7 Gy of X-ray irradiation. However, no such change was detected in brain, spleen and cultured cells. The data indicate that radiation-induced alteration in genomic DNA methylation is not ubiquitous among different tissues and cells.

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