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Comparative Study
. 1978 Sep;9(3):347-52.
doi: 10.1016/0091-3057(78)90295-2.

Effects of passive immunization against morphine on heroin self-administration

A Killian, K Bonese, R M Rothberg, B H Wainer, C R Schuster
Comparative Study

Effects of passive immunization against morphine on heroin self-administration

A Killian et al. Pharmacol Biochem Behav. 1978 Sep.

Abstract

Antimorphine antibodies produced in Rhesus monkeys immunized with morphine-6-hemisuccinate-BSA were passively administered to recipient monkeys trained to self-administer heroin and cocaine. Following antibody administration, changes in heroin self-administration behavior were observed which were similar to those achieved with low doses of naloxone. Both manipulations increased heroin self-administration without affecting cocaine responding.

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