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Review
. 1998 Sep;5(9):720-8.
doi: 10.1038/sj.cdd.4400412.

Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation

C Fiorentini  1 , M Gauthier, G Donelli, P Boquet
Affiliations
Review

Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation

C Fiorentini et al. Cell Death Differ. 1998 Sep.

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

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