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. 1999 Mar 8;9(5):731-6.
doi: 10.1016/s0960-894x(99)00057-8.

Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives

M K Kundu  1 , M K Kundu, N Sundar, S K Kumar, S V Bhat, S Biswas, N Valecha
Affiliations

Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives

M K Kundu et al. Bioorg Med Chem Lett. .

Abstract

Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials. The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level.

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