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. 1999 Apr;47(4):456-62.
doi: 10.1111/j.1532-5415.1999.tb07239.x.

Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?

P Barberger-Gateau  1 , C Fabrigoule, C Helmer, I Rouch, J F Dartigues
Affiliations

Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?

P Barberger-Gateau et al. J Am Geriatr Soc. 1999 Apr.

Abstract

Objective: To estimate the predictive value of four IADLs on 3- and 5-year incident dementia.

Design: Prospective cohort study.

Setting: A community survey in 37 randomly selected parishes.

Subjects: A random sample of French community dwellers aged 65 and older included in the PAQUID study followed-up at 3 (1582 subjects) and 5 years (1283 subjects).

Main outcome measures: Incidence of dementia at 3 and 5 years, diagnosed by two-step screening: (1) MMS and DSM-III-R; (2) diagnosis of dementia confirmed by a neurologist.

Results: A score summing up the number of dependencies at baseline on four IADLs is a predictor of 3-year but not of 5-year incident dementia. Increase in the level of dependence between baseline and 3-year follow-up is associated with an increased risk of incident dementia at 5-year follow-up.

Conclusion: These four IADLs can help to identify older subjects at high risk of dementia who should then undergo neuropsychological testing.

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