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. 1999 May;37(5):1567-9.
doi: 10.1128/JCM.37.5.1567-1569.1999.

Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant

A Doglio  1 , C Laffont, F X Caroli-Bosc, P Rochet, J Lefebvre
Affiliations

Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant

A Doglio et al. J Clin Microbiol. 1999 May.

Abstract

The first and second generations of the Cobas Amplicor HCV assay were compared among patients at risk of hepatitis C virus (HCV) infection. The second-generation test was found to be of greater sensitivity and of good specificity among clinical specimens containing HCV RNA of different genotypes. Finally, this new test is shown to predict the outcome of interferon therapy better.

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Figures

FIG. 1
FIG. 1
Overall performance of CA v1.0 and CA v2.0. HCV RNA was detected with both Cobas assays in 187 clinical specimens consecutively collected from patients at risk of HCV infection. Data are the numbers of samples with the indicated test results. Italic numbers in parentheses are the numbers of HCV-seropositive patients in each group.
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