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. 1999 May;37(5):1632-3.
doi: 10.1128/JCM.37.5.1632-1633.1999.

Ability of a rapid serology test to detect seroconversion to herpes simplex virus type 2 glycoprotein G soon after infection

R L Ashley  1 , M Eagleton, N Pfeiffer
Affiliations

Ability of a rapid serology test to detect seroconversion to herpes simplex virus type 2 glycoprotein G soon after infection

R L Ashley et al. J Clin Microbiol. 1999 May.

Abstract

Sera (n = 188) from 29 patients with first-episode genital herpes simplex virus type 2 (HSV-2) infections were tested by POCkit-HSV-2 and Western blot (WB) to determine the speed of seroconversion. The median time to detection of HSV-2 antibody was 13 days (range, 3 to 102 days) by the POCkit-HSV-2 test versus 13 days (range, 2 to 58 days) for WB.

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Figures

FIG. 1
FIG. 1
Kaplan-Meier plots showing time to seroconversion determined by the POCkit-HSV-2 test compared with the time to develop a limited (A) or full (B) HSV Western blot profile.
See this image and copyright information in PMC

References

    1. Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 or 2. Ann Intern Med. 1991;115:520–526. - PubMed
    1. Ashley R L. Current concepts of laboratory diagnosis of herpes simplex infection. In: Sacks S L, Straus S E, Whitley R J, Griffiths P D, editors. Clinical management of herpes viruses. Washington, D.C: IOS Press; 1995. pp. 137–171.
    1. Ashley R L, Wu L, Pickering J, Tu M, Schnorenberg L. Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies. J Clin Microbiol. 1998;36:294–295. - PMC - PubMed
    1. Ashley R L, Pickering J, Pfeiffer N, Wei S, Wu L. Abstracts of the 98th General Meeting of the American Society for Microbiology. Washington, D.C: American Society for Microbiology; 1998. Early diagnosis of first episode genital herpes simplex virus (HSV) infection by enzyme immunoassay (EIA) for type-specific IgM antibodies, abstr. C-392; p. 196.
    1. Ashley R L, Eagleton M. Evaluation of a novel point-of-care test for antibodies to herpes simplex virus type 2. Sex Transm Infect. 1998;74:228–229. - PubMed

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