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. 1999 Mar;20(3):119-24.
doi: 10.1016/s0167-5699(98)01395-4.

Immune cell signaling defects in lupus: activation, anergy and death

G C Tsokos  1 , S N Liossis
Affiliations

Immune cell signaling defects in lupus: activation, anergy and death

G C Tsokos et al. Immunol Today. 1999 Mar.

Abstract

Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.

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