Review
doi: 10.1016/s0968-0004(99)01358-4.
Separating sister chromatids
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- PMID: 10203756
- DOI: 10.1016/s0968-0004(99)01358-4
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Review
Separating sister chromatids
Trends Biochem Sci.
1999 Mar.
Abstract
Loss of cohesion between sister chromatids triggers their segregation during anaphase. Recent work has identified both a cohesin complex that holds sisters together and a sister-separating protein, separin, that destroys cohesion. Separins are bound by inhibitory proteins whose proteolysis at the metaphase-anaphase transition is mediated by the anaphase-promoting complex and its activator protein CDC20 (APCCDC20). When chromosomes are misaligned, a surveillance mechanism (checkpoint) blocks sister separation by inhibiting APCCDC20. Defects in this apparatus are implicated in causing aneuploidy in human cells.
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