Comment on

• Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

  Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Wolfe MS, et al. Nature. 1999 Apr 8;398(6727):513-7. doi: 10.1038/19077. Nature. 1999. PMID: 10206644
• A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

  De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645
• Presenilin is required for activity and nuclear access of Notch in Drosophila.

  Struhl G, Greenwald I. Struhl G, et al. Nature. 1999 Apr 8;398(6727):522-5. doi: 10.1038/19091. Nature. 1999. PMID: 10206646
• Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

  Ye Y, Lukinova N, Fortini ME. Ye Y, et al. Nature. 1999 Apr 8;398(6727):525-9. doi: 10.1038/19096. Nature. 1999. PMID: 10206647