Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 1999 Apr 2;83(4):322-5.

Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data

D J Allingham-Hawkins  1 , R Babul-Hirji, D Chitayat, J J Holden, K T Yang, C Lee, R Hudson, H Gorwill, S L Nolin, A Glicksman, E C Jenkins, W T Brown, P N Howard-Peebles, C Becchi, E Cummings, L Fallon, S Seitz, S H Black, A M Vianna-Morgante, S S Costa, P A Otto, R C Mingroni-Netto, A Murray, J Webb, F Vieri, et al.
Affiliations
Multicenter Study

Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data

D J Allingham-Hawkins et al. Am J Med Genet. .

Abstract

The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Distribution of subjects among the age and mutation categories (number of subjects is indicated above each bar).
Fig. 2
Fig. 2
Proportion of subjects in each of the age and mutation categories that experienced premature ovarian failure (proportion of subjects with POF is indicated above each bar).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol. 1986;67:604–606. - PubMed
    1. Cronister A, Schreiner R, Wittenberger M, Amiri K, Harris K, Hagerman RJ. Heterozygous fragile X females: historical, physical, cognitive, and cytogenetic features. Am J Med Genet. 1991;38:269–274. - PubMed
    1. Feng Y, Lakkis L, Devys D, Warren ST. Quantitative comparison of FMR1 gene expression in normal and premutation alleles. Am J Hum Genet. 1995;56:106–113. - PMC - PubMed
    1. Partington MW, Moore DY, Turner GM. Confirmation of early menopause in fragile X carriers. Am J Med Genet. 1996;64:370–372. - PubMed
    1. Schwartz CE, Dean J, Howard-Peebles PN, Bugge M, Mikkelsen M, Tommerup N, Hull C, Hagerman R, Holden JJA, Stevenson RE. Obstetrical and gynecological complications in fragile X carriers: a multicenter study. Am J Med Genet. 1994;51:400–402. - PubMed

Publication types