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Multicenter Study
. 1999 Apr 2;83(4):322-5.

Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data

D J Allingham-Hawkins  1 , R Babul-Hirji, D Chitayat, J J Holden, K T Yang, C Lee, R Hudson, H Gorwill, S L Nolin, A Glicksman, E C Jenkins, W T Brown, P N Howard-Peebles, C Becchi, E Cummings, L Fallon, S Seitz, S H Black, A M Vianna-Morgante, S S Costa, P A Otto, R C Mingroni-Netto, A Murray, J Webb, F Vieri, et al.
Affiliations
Multicenter Study

Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data

D J Allingham-Hawkins et al. Am J Med Genet. .

Abstract

The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.

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Figures

Fig. 1
Fig. 1
Distribution of subjects among the age and mutation categories (number of subjects is indicated above each bar).
Fig. 2
Fig. 2
Proportion of subjects in each of the age and mutation categories that experienced premature ovarian failure (proportion of subjects with POF is indicated above each bar).
See this image and copyright information in PMC

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