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Review
. 1999 Apr;11(2):203-10.
doi: 10.1016/s0955-0674(99)80027-1.

Costimulatory regulation of T cell function

C A Chambers  1 , J P Allison
Affiliations
Review

Costimulatory regulation of T cell function

C A Chambers et al. Curr Opin Cell Biol. 1999 Apr.

Abstract

During the past several years, the critical role of costimulatory molecules in regulating T cell responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA-4 downmodulates T cell responses. An understanding of the integration of the signals mediated by costimulatory molecules and the T cell receptor at the cellular and molecular levels is just beginning to be achieved.

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