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. 1999 Apr 14;1445(1):154-9.
doi: 10.1016/s0167-4781(99)00029-9.

Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1

V Cattori  1 , U Eckhardt, B Hagenbuch
Affiliations

Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1

V Cattori et al. Biochim Biophys Acta. .

Abstract

To isolate the murine Na+/taurocholate cotransporting polypeptide (Ntcp), we screened a mouse liver cDNA library and identified Ntcp1, encoding a 362 amino acid protein and Ntcp2, encoding a 317 amino acid protein which had a shorter C-terminal end. Both isoforms mediated saturable Na+-dependent transport of taurocholate when expressed in Xenopus laevis oocytes. Analysis of the gene revealed that Ntcp2 is produced by alternative splicing where the last intron is retained.

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