Comparative Study
[Toxicity and cumulative properties of carminomycin, rubomycin and adriamycin at different times of use]
[Article in
Russian]
- PMID: 1020931
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Comparative Study
[Toxicity and cumulative properties of carminomycin, rubomycin and adriamycin at different times of use]
[Article in
Russian]
Antibiotiki.
1976 Nov.
Abstract
LD50 of karminomycin, rubomycin and adriamycin were determined after their single administration or 3-, 5-, 10- and 15-fold administration once a day to 540 hybrid male mice F1(C57B1 X CBA). Comparison of the cumulative indices for these antibiotics showed that after injections they were close. After 5 injections the cumulative properties were more pronounced for adriamycin. After 10 or 15 injections the cumulative properties were less pronounced for karminomycin.
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