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. 1998 Oct;15(10):1033-7.
doi: 10.1023/a:1006950311937.

Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma

B C Nan  1 , D M Shao, H L Chen, Y Huang, J X Gu, Y B Zhang, Z G Wu
Affiliations

Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma

B C Nan et al. Glycoconj J. 1998 Oct.

Abstract

The activities of three N-acetylglucosaminyltransferases (GnT III, GnT IV and GnT V) were determined in 10 samples of pancreatic carcinoma (PCa) and compared with those in 9 samples of normal pancreatic tissue (NP). It was found that the specific activities of GnT III, GnT IV and GnT V increased in all of the PCa samples. GnT III increased most significantly, up to 22.3 fold of normal, GnT IV was elevated 12.3 fold, while GnT V increased only 2.4 fold. The elevation of GnTs in pancreatic carcinoma was consistent with the increase in the number of antenna and bisecting GlcNAc structures in N-glycans of pancreatic ribonuclease (RNase) as assessed by Con A affinity chromatography. Polycytidylate specific RNase from the serum of PCa patients showed the same structural changes as that found in in N-glycans of the RNase from PCa tissue.

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