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. 1999 Apr;62(4):650-2.
doi: 10.1021/np980511n.

Sclerotigenin: A new antiinsectan benzodiazepine from the sclerotia of penicillium sclerotigenum

BK Joshi  1 , JB Gloer, DT Wicklow, PF Dowd
Affiliations

Sclerotigenin: A new antiinsectan benzodiazepine from the sclerotia of penicillium sclerotigenum

BK Joshi et al. J Nat Prod. 1999 Apr.

Abstract

A new benzodiazepine, sclerotigenin (1), was isolated from organic extracts of the sclerotia of Penicillium sclerotigenum (NRRL 3461) along with two known griseofulvin analogues. The structure of 1 was determined primarily by analysis of 1H NMR, 13C NMR, HMQC, and HMBC data. Compound 1 was the major component of the CH2Cl2 extract of P. sclerotigenum sclerotia and is responsible for most of the antiinsectan activity of the extract against the crop pest Helicoverpa zea.

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