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Review
. 1999 Apr;7(4):160-5.
doi: 10.1016/s0966-842x(99)01487-0.

Apoptosis: an innate immune response to virus infection

H Everett  1 , G McFadden
Affiliations
Review

Apoptosis: an innate immune response to virus infection

H Everett et al. Trends Microbiol. 1999 Apr.

Abstract

Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that can function as 'alarm bells' to transmit pro-apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.

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