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Review
. 1999 Apr;9(2):261-73.
doi: 10.1111/j.1750-3639.1999.tb00225.x.

Autoimmunity in paraneoplastic neurological syndromes

B Giometto  1 , B Taraloto, F Graus
Affiliations
Review

Autoimmunity in paraneoplastic neurological syndromes

B Giometto et al. Brain Pathol. 1999 Apr.

Abstract

In patients with Paraneoplastic Neurological Disorders, the researcher detected several autoantibodies reacting with neuronal antigens and tumors; their characteristics supported the hypothesis that autoimmunity plays a part in these diseases and gave impetus to the study of these neurological disorders. The relationship between detection of anti-neuronal antibodies, clinical syndromes, and certain types of tumors suggested the utility of these antibodies as a new tool for clinical diagnosis, although their function in the pathogenesis of the various syndromes is still unclear. This paper intends to review the characteristics of the anti-neuronal antibodies so far identified, their correlation with clinical syndromes, and the function of antigens. In addition, the paper will offer some insights on the immunological mechanisms of neuronal damage and on treatment options.

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References

    1. Altermatt HJ, Rodriguez M, Scheithauer BW, Lennon VA (1991) Paraneoplastic anti‐Purkinje and type I anti‐neuronal nuclear autoantibodies bind selectively to central, peripheral, and autonomic nervous system cells. Lab Invest 65: 412–420. - PubMed
    1. Anderson NE, Rosenblum, MK , Posner, JB (1988) Paraneoplastic cerebellar degeneration: clinical‐immunological correlation. Ann Neurol 24: 559–567. - PubMed
    1. Antoine JC, Honnorat J, Thomas Anterion C, Aguera M, Absi L, Fournel P, Michel D (1995). Limbic encephalitis and immunologial perturbations in two patients with thymoma. J Neurol Neurosurg Psychiatr 58: 706–710. - PMC - PubMed
    1. Bain PG, Motomura M, Newson‐Davies J, Misbah SA, Chapel HM, Lee ML, Vincent A, Lang B (1996) Effects of intravenous immunoglobulin on muscle weakness and calcium‐channel autoantibodies in the Labert‐Eaton myastenic syndrome. Neurology 47: 678–683. - PubMed
    1. Baker, ME , Kirbs, DR , Korobkia, M , Bowie, JD , Filston, HC. (1985) The association of neuroblastoma and myoclonic encephalopathy: an imaging approach. Pediatr Radiol 15: 185–189. - PubMed