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Comparative Study
. 1999 Apr;49(4):362-6.
doi: 10.1046/j.1365-3083.1999.00522.x.

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P J Cardona  1 , A Cooper, M Luquín, A Ariza, F Filipo, I M Orme, V Ausina
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Free article
Comparative Study

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P J Cardona et al. Scand J Immunol. 1999 Apr.
Free article

Abstract

The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

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