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. 1999 May;43(5):1298-300.
doi: 10.1128/AAC.43.5.1298.

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

M Akova  1 , D Gür, D M Livermore, T Kocagöz, H E Akalin
Affiliations

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

M Akova et al. Antimicrob Agents Chemother. 1999 May.

Abstract

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

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Figures

FIG. 1
FIG. 1
Interactions of different antibiotic combinations at pH 7.0 (A) and at pH 5.0 (B) against 20 B. melitensis isolates. R, rifampin; A, azithromycin; O, ofloxacin; D, doxycycline; S, streptomycin.
See this image and copyright information in PMC

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