Status epilepticus: new concepts

Abstract

Generalized convulsive status epilepticus is a neurological emergency characterized by abnormally prolonged seizures. This review emphasizes recent developments that bear on our understanding of the pathophysiology and management of status epilepticus. Topics include GABAA receptor modulation during prolonged seizures, the role of genetics in susceptibility to status epilepticus, neuron-specific enolas, the Veterans Administration Cooperative Study Group trial comparison of various drug regimens, utility of the electroencephalogram in patient monitoring, emerging drug therapies and patient management in out-of-hospital settings.