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. 1999 Jun;179(6):1542-8.
doi: 10.1086/314757.

Longitudinal quantification of human immunodeficiency virus type 1 DNA and RNA in long-term nonprogressors

C Broström  1 , U Visco-Comandini, Z Yun, A Sönnerborg
Affiliations

Longitudinal quantification of human immunodeficiency virus type 1 DNA and RNA in long-term nonprogressors

C Broström et al. J Infect Dis. 1999 Jun.

Abstract

Twenty patients with human immunodeficiency virus type 1 (HIV-1) infection for >7 years, no HIV-1-related symptoms, no treatment, and CD4+ cell counts >500/microL were included in a prospective study in 1993. Four years later, 12 patients had progressed (SPs), while 8 had not (long-term nonprogressors [LTNPs]). At inclusion, HIV-1 RNA, but not DNA, levels were higher in SPs. During follow-up, a consistent increase in HIV-1 RNA was seen in only 1 LTNP. In 2 LTNPs, plasma viremia was persistently undetectable or <110 copies/mL. Infectious virus was isolated from only 1 LTNP and from 11 SPs. In 4 LTNPs, HIV-1 DNA levels decreased spontaneously with time. The restricted viral replication and the declining HIV-1 DNA levels suggest that the HIV-1 infection can be controlled efficiently in a few LTNPs, leading to a decrease in the total virus burden with time.

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