Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Feb;107 Suppl 1(Suppl 1):37-47.
doi: 10.1289/ehp.99107s137.

Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer

A Hirvonen  1
Affiliations
Review

Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer

A Hirvonen. Environ Health Perspect. 1999 Feb.

Abstract

The variation in individual responses to exogenous agents is exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in cancer or other diseases in which an environmental component can be presumed. Many of the studies have shown an elevated disease proneness for individuals carrying the potential at-risk alleles of metabolic genes, but a number of controversial results have also been reported. This article is an overview of the data published to date on metabolic genotypes related to individual susceptibility to cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Clin Nutr. 1995 Mar;61(3 Suppl):666S-669S - PubMed
    1. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2384-7 - PubMed
    1. Pharmacogenetics. 1994 Oct;4(5):242-6 - PubMed
    1. Ann Med. 1994 Dec;26(6):443-52 - PubMed
    1. Carcinogenesis. 1995 Mar;16(3):643-8 - PubMed

LinkOut - more resources