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. 1999 Mar;34(3):235-41.
doi: 10.1007/s11745-999-0358-8.

Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

Y Park  1 , J M Storkson, K J Albright, W Liu, M W Pariza
Affiliations

Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

Y Park et al. Lipids. 1999 Mar.

Abstract

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.

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