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Review
. 1999 Apr;8(2):96-108.
doi: 10.1111/j.1600-0625.1999.tb00355.x.

Signal transduction in keratinocytes

V Mitev  1 , L Miteva
Affiliations
Review

Signal transduction in keratinocytes

V Mitev et al. Exp Dermatol. 1999 Apr.

Abstract

Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and their proliferation and differentiation are stimulated by a variety of biological factors. The major mechanism by which cells (keratinocytes) respond to extracellular signals, is changing in protein phosphorylation. The protein phosphorylation is a consequence of the ligand/receptor binding which leads to activation of several transduction systems. In this review we emphasize on different signal transduction pathways in keratinocytes (tyrosine kinases, PKA, PKC, MAPK, casein kinase 2 etc.).

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