Comment on

• Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.

  Delhase M, Hayakawa M, Chen Y, Karin M. Delhase M, et al. Science. 1999 Apr 9;284(5412):309-13. doi: 10.1126/science.284.5412.309. Science. 1999. PMID: 10195894
• Limb and skin abnormalities in mice lacking IKKalpha.

  Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S. Takeda K, et al. Science. 1999 Apr 9;284(5412):313-6. doi: 10.1126/science.284.5412.313. Science. 1999. PMID: 10195895
• Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.

  Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. Hu Y, et al. Science. 1999 Apr 9;284(5412):316-20. doi: 10.1126/science.284.5412.316. Science. 1999. PMID: 10195896
• Severe liver degeneration in mice lacking the IkappaB kinase 2 gene.

  Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM. Li Q, et al. Science. 1999 Apr 9;284(5412):321-5. doi: 10.1126/science.284.5412.321. Science. 1999. PMID: 10195897