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Clinical Trial
. 1976 Dec;48(12):1187-9.
doi: 10.1093/bja/48.12.1187.

Reactions to intravenous injections of diazepam

H Siebke, B B Ellertsen, B Lind
Free article
Clinical Trial

Reactions to intravenous injections of diazepam

H Siebke et al. Br J Anaesth. 1976 Dec.
Free article

Abstract

Local reactions during and after i.v. injection of two different formulations of diazepam were studied. Two-thirds of the patients felt pain during the injection. Verfied or probable thrombophlebitis occurred with increasing frequency following operation, indicating a late onset. One month after discharge, 29% of those who had received diazepam in glycoferol-alcohol-benzoic acid complained of tender injection sites, compared with only 10% of the patients who received diazepam in cremophor EL. The difference is significant, indicating an influence of the solvent system.

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