doi: 10.1083/jcb.68.3.781.
Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
- PMID: 1025156
- PMCID: PMC2109658
- DOI: 10.1083/jcb.68.3.781
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Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes
J Cell Biol.
1976 Mar.
Abstract
Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites.
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