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. 1976 Mar;68(3):781-7.
doi: 10.1083/jcb.68.3.781.

Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes

S Hoffstein, R Soberman, I Goldstein, G Weissmann

Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes

S Hoffstein et al. J Cell Biol. 1976 Mar.

Abstract

Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites.

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References

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