Studies on the role of suppressor cells in specific unresponsiveness to DNCB

Abstract

Lymph nodes--and to a lesser extent spleen cells--from guinea-pigs tolerant to DNCB contact sensitivity, when injected into normal syngeneic guinea-pigs, decrease the ability of the recipients to become sensitized to contact with DNCB. The difference between the complete tolerance transferred by parabiosis with tolerant partners and the partial tolerance induced by transfer of tolerant cells can be explained by the different numbers of cells homing in the recipients. The tolergen does not play any role in the transfer of tolerance.