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. 1978 Dec;276(5690):780-4.
doi: 10.1038/276780a0.

Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity

O Valbuena, K B Marcu, M Weigert, R P Perry

Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity

O Valbuena et al. Nature. 1978 Dec.

Abstract

The number of germline genes specifying the variable sequences of the Vkappa21 group of light chains was determined by saturation hybridisation analysis to be four to six. This gene multiplicity is considerably less than the total variability in the group, indicating that kappa-chain diversity is generated by somatic mutations in both framework and complementarity-determining (hypervariable) regions.

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