Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Apr;17(2):115-8.
doi: 10.1007/BF02974234.

Isolation of isoguanosine from Croton tiglium and its antitumor activity

J H Kim  1 , S J Lee, Y B Han, J J Moon, J B Kim
Affiliations

Isolation of isoguanosine from Croton tiglium and its antitumor activity

J H Kim et al. Arch Pharm Res. 1994 Apr.

Abstract

This paper describes the isolation of isoguanosine from Croton tiglium L. and its cytotoxic effect against several tumor cell lines in culture and newly reports that isoguanosine has an antitumor activity against implanted S-180 ascitic tumor mice. Isoguanosine is effective at the dose of 24 mg/kg/day x 5, with T/C value of 168%. Isoguanosine inhibits the growth of S-180 and Ehrlich solid tumor in mice at the optimal doses of 96 mg/kg/day x 12 and 48 mg/kg/day x 12, with 1-T/C values of 65% and 60%, respectively.

PubMed Disclaimer

References

    1. J Biol Chem. 1952 May;197(2):591-600 - PubMed
    1. Science. 1981 May 1;212(4494):557-8 - PubMed
    1. J Immunol Methods. 1983 Dec 16;65(1-2):55-63 - PubMed
    1. Cancer Res. 1969 Mar;29(3):687-96 - PubMed
    1. Anal Biochem. 1974 Oct;61(2):367-78 - PubMed

Publication types