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. 1999 May 7;68(1-2):193-7.
doi: 10.1016/s0169-328x(99)00090-x.

Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice

L S Brady  1 , M Herkenham, R B Rothman, J S Partilla, M König, A M Zimmer, A Zimmer
Affiliations

Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice

L S Brady et al. Brain Res Mol Brain Res. .

Abstract

Mu and delta opioid receptors were labeled in enkephalin knockout mice by quantitative autoradiography. Discrete, large increases (100-300%) were found in limbic forebrain structures for mu binding and striatum and pallidum for delta binding. The up-regulation of opioid receptors may reflect a form of 'denervation supersensitivity. ' The receptor up-regulation in limbic areas is consistent with the increased emotional and aggressive behaviors observed in the enkephalin knockout mice.

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