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Review
. 1999 May;6(5):R137-46.
doi: 10.1016/s1074-5521(99)80071-4.

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

S G Sarafianos  1 , K Das, J Ding, P L Boyer, S H Hughes, E Arnold
Affiliations
Review

Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

S G Sarafianos et al. Chem Biol. 1999 May.

Abstract

Comparison of the recently solved structure of HIV-1 reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS.

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