Review
doi: 10.1016/S0959-437X(99)80029-X.
Stopped at the border: boundaries and insulators
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- PMID: 10322134
- DOI: 10.1016/S0959-437X(99)80029-X
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Review
Stopped at the border: boundaries and insulators
Curr Opin Genet Dev.
1999 Apr.
Abstract
Boundaries in chromatin are often marked by the presence of insulator elements. New results in Drosophila have identified an insulator with a proven boundary function essential for development. Other studies suggest a connection between the activity of some insulators and Drosophila trithorax-Group and Polycomb-Group genes. Several examples of vertebrate insulators have now been found; their locations suggest important boundary functions. Enhancer-blocking studies in oocytes and position-effect studies in transformed cells shed new light on insulator mechanisms.
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