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Review
. 1999 Apr;11(2):152-6.
doi: 10.1016/s0952-7915(99)80026-0.

Peripheral T cell survival

A A Freitas  1 , B Rocha
Affiliations
Review

Peripheral T cell survival

A A Freitas et al. Curr Opin Immunol. 1999 Apr.

Abstract

T cell survival in the periphery is an active process, depending on continuous TCR engagement by peptide-MHC complexes and/or response to environmental cytokines. Naive T cells require interactions with the MHC restricting element. The survival requirements of memory T cells are as yet insufficiently characterized, but MHC-restricted interactions are not necessary.

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