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Review
. 1999 Apr;2(2):126-30.
doi: 10.1016/S1369-5274(99)80022-8.

DNA structure and transcription

X Dai  1 , L B Rothman-Denes
Affiliations
Review

DNA structure and transcription

X Dai et al. Curr Opin Microbiol. 1999 Apr.

Abstract

Regulation of transcription occurs through complex interactions of RNA polymerase and accessory proteins with specific DNA sequences and with each other. The DNA template topology influences the interaction of RNA polymerase with the promoter and its response to repressors, activators and the intracellular milieu through the formation of altered DNA structures or of nucleoprotein complexes. Recent developments on the role of DNA structures in transcription regulation are discussed.

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