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Comparative Study
. 1999 Spring;7(2):151-9.

Late-life depression as a possible predictor of dementia: cross-sectional and short-term follow-up results

R van Reekum  1 , M Simard, D Clarke, M A Binns, D Conn
Affiliations
  • PMID: 10322243
Comparative Study

Late-life depression as a possible predictor of dementia: cross-sectional and short-term follow-up results

R van Reekum et al. Am J Geriatr Psychiatry. 1999 Spring.

Abstract

The authors explored cognitive functioning of a group of elderly subjects with depression. The group as a whole, and, in particular, the late-onset group (LOD), demonstrated cognitive impairment on the Mattis Dementia Rating Scale (MDRS). Subgroup differences were significant at P=0.004. This between-group difference was not seen when age and level of education were controlled. In the LOD group, 47.5% (vs. 31.5% of the early-onset group [P=0.025]), scored below the cutoff for dementia. Age-at-onset status in a logistic regression model predicted MDRS category, and treatment of the depression had little effect on cognition. Results support the hypothesis that late-life depression, particularly LOD, is associated with cognitive impairment that may represent early AD.

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