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. 1999 Apr;4(2):160-170.
doi: 10.1016/s1461-5347(99)00136-4.

Extrusion and spheronization in the development of oral controlled-release dosage forms

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Extrusion and spheronization in the development of oral controlled-release dosage forms

R Gandhi et al. Pharm Sci Technol Today. 1999 Apr.

Abstract

The concept of multiparticulate dosage forms was introduced in the 1950s. With the increasing use of multiparticulate controlled release (CR) oral dosage forms, in recent times there has been a rise in interest in the methods of preparing these dosage forms. A method that has gained increased usage over the past few years is that of extrusion and spheronization. It has been extensively explored as a potential technique and also as a future method of choice for preparation of multiparticulate CR dosage forms. In this review an attempt is made to outline the general process of extrusion and spheronization and to assess its importance in the development of multiparticulate CR oral dosage forms.

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