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. 1999 Apr;10(3):81-85.
doi: 10.1016/s1043-2760(98)00124-6.

The Role of Genomic Imprinting of Galpha in the Pathogenesis of Albright Hereditary Osteodystrophy

LS Weinstein  1 , S Yu
Affiliations

The Role of Genomic Imprinting of Galpha in the Pathogenesis of Albright Hereditary Osteodystrophy

LS Weinstein et al. Trends Endocrinol Metab. 1999 Apr.

Abstract

Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactivating mutations of the gene encoding the alpha-subunit of the G protein Gs. The Gsalpha gene is a complex gene that uses various alternative promoters and produces various protein products. Recently, it has been shown that this gene is imprinted in a tissue-specific manner. The role of tissue-specific imprinting of Gsalpha in the pathogenesis of AHO is discussed.

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