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Review
. 1999 Apr;24(4):142-5.
doi: 10.1016/s0968-0004(99)01368-7.

Retinoblastoma protein meets chromatin

A Brehm  1 , T Kouzarides
Affiliations
Review

Retinoblastoma protein meets chromatin

A Brehm et al. Trends Biochem Sci. 1999 Apr.

Abstract

The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RB repression have revealed that RB can regulate transcription by effecting changes in chromatin structure. These findings point towards a link between chromatin regulation and cancer.

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